Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15
نویسندگان
چکیده
منابع مشابه
Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements
Complex genomic rearrangements (CGRs) consisting of two or more breakpoint junctions have been observed in genomic disorders. Recently, a chromosome catastrophe phenomenon termed chromothripsis, in which numerous genomic rearrangements are apparently acquired in one single catastrophic event, was described in multiple cancers. Here, we show that constitutionally acquired CGRs share similarities...
متن کاملSupernumerary chromosome 1 in interphase nuclei of atypical germ cells in paraffin-embedded human seminiferous tubules.
The so-called atypical germ cells or cells of carcinoma in situ morphologically resemble neoplastic cells in seminoma. Since seminomas show numerical aberrations of chromosome 1 we have used a DNA probe specific for chromosome region 1q12 to determine whether such aberrations can be detected in atypical germ cell nuclei in paraffin-embedded seminiferous tubules as well. One-third of intratubula...
متن کاملSperm analyses, genetic counselling and therapy in an infertile carrier of a supernumerary marker chromosome 15.
PURPOSE A supernumerary marker chromosome (SMC) was analysed after lymphocyte culture of a patient with oligoasthenoteratozoospermia (OAT) before ICSI treatment. MATERIAL AND METHODS By additional molecular cytogenetic investigations the marker could be identified as a heterochromatic derivate of chromosome 15 [karyotype: 47,XY,+der(15)]. RESULTS Sperm analyses by interphase FISH showed a n...
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The promoter-cloning plasmid pBRH4 (a derivative of pBR322 with a partially deleted promoter of the tet gene) is shown to contain a sequence which is located near the EcoRI site and can operate as an effective Pribnow box, but is not the remainder of the deletion-inactivated tet promoter of pBR322. If there is a sequence homologous to the '-35' promoter region at the border of the DNA fragment ...
متن کاملPossible supernumerary chromosome associated with hypodontia.
Thosen (Amer. J. phys. Anthrop., [n.s. 10:155, 1952) listed dominant, irregular donsinant, recessive, and sex-linked genes as the explanation for hypodontia. Grahnhn (Odont. Revy, 7, Sup)pl. 3, 1956) concluded from studies of Swedish families that dominant genes were involved in the majority of cases of hypodontia and that probably a number of genetic entities were associated with its occurrenc...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2008
ISSN: 1471-2156
DOI: 10.1186/1471-2156-9-2